Published in BMC Complementary Medicine and Therapies, the work of scientists from The Institute for Biomedical and Bioscience Research, University of Buckingham; the European Genomic Institute for Diabetes, Hospital Claude Huriez; and Sibelius Ltd., identifies changes in biomarkers of inflammation and tissue remodeling that result from the use of sage extract on in vitro, human primary cell translational disease models.
The work documents applicability of the BioMAP Platform beyond standard biopharmaceutical applications and demonstrates the portfolio breadth of Eurofins Discovery in providing testing for life enzyme assays and biomarker screening and profiling services in the neuro-inflammatory and neurodegenerative therapeutic space.
One of the challenges to evaluating potential nutritional interventions for neurodegeneration and other therapeutic areas is assessment of relevant biomarkers in standardized clinically validated in vitro disease models sensitive enough to detect changes in mixtures as well as purified drug candidates. The BioMAP Diversity PLUS® Panel can provide this key assessment while covering a broad range of tissue and disease biology. The panel reports on biomarkers common across many diseases that involve inflammation, is validated with clinically approved drugs, and provides results based on advanced data analytics powered by a comprehensive Reference Database.
Eurofins Discovery is recognized as the industry leader for providing drug discovery researchers the largest and most diverse portfolio of standard and custom in vitro safety & pharmacology assays and panels for drug screening and profiling. In addition to in vitro safety pharmacology strengths, we also offer a broad portfolio of over 3,500 drug discovery services and 1,800 products. These include in vitro assays, cell-based phenotypic assays, safety pharmacology and efficacy, ADME toxicology, medicinal chemistry design, synthetic chemistry, and custom proteins and assay development capabilities. We support a variety of drug discovery targets such as GPCRs, Kinases, Ion Channels, Nuclear Hormone Receptors and other proteins & enzymes. The Eurofins Discovery capabilities, expertise, knowledge and skill sets enable the company to provide clients the benefit of being able to work with a single outsourcing provider (CRO) for all their drug discovery programs.
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